Global warming is when the world temperature is increasing and many natural disasters happen such as droughts, hurricanes, etc. Using air conditioners can affect to increase of global temperature. Engineers try to find environmentally friendly refrigerants. R290 is chosen by refrigeration engineers because it is one of HC (Hydrocarbon) refrigerants, and has 0 ODP (Ozone Depletion Potential) and 3 GWP (Global Warming Potential). Unfortunately, R290 is flammable so it is necessary to design an air conditioner that can prevent leaks or accidents. AC-Split was designed using R290 refrigerant. In this design, cycle, dimension, and simulation analysis was carried out using CoolPack software and AC-Split design using SOLIDWORKS 2020 software using available catalog data. The analysis and simulation result shows that the design of the Split AC with R290 refrigerant has 0.7 kW of compressor work with 2.91 kW cooling capacity. AC-Split is built with specifications of compressor 2/3 HP with Danfoss brand along with receiver and compressor oil brand ISO VG 32 ESTER, evaporator 2.73 KW with LU-VE brand, and condenser 4.9 kW brand of Thermocoil.