G6PD Deficiency in Dehradun Population

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency increases the vulnerability of erythrocytes to oxidative stress. Clinical presentations include acute hemolytic anemia, chronic hemolytic anaemia, neonatal hyperbilirubinemia, and an absence of clinical symptoms. The present study on incidence of Glucose 6 phosphate dehydrogenase was carried out in population of Dehradun region. The study of glucose 6 phosphate dehydrogenase enzyme on the 300 cases was done with the help of commercially available kit for detecting erythrocyte glucose 6 phosphate dehydrogenase enzymes. Present study concludes that G6PD deficiency is prevalent in population of Dehradun, region, it is of mild type. It is recommended that every subject should get tested for G6PD deficiency and carry G6PDstatus card while visiting doctor.

Country : India

1 Rashmi2 D.K.Awasthi3 Gyanendra Awasthi

  1. Department of Medical Lab Technology, Sanskriti Univeristy, Mathura, India
  2. Department of Chemistry, JNM (PG) College, Lucknow, India
  3. Department of Biochemistry, Dolphin (PG) Institute of Biomedical and Natural Sciences, Dehradun, India

IRJIET, Volume 6, Issue 4, April 2022 pp. 54-58

doi.org/10.47001/IRJIET/2022.604009

References

  1. Ruwende C, Hill A. Glucose-6-phosphate dehydrogenase deficiency and malaria. J Mol Med 1998; 76:581-8.
  2. Mockenhaupt FP, Mandelkow J, Till H, Ehrhardt S, Eggelte TA, Bienzle U. Reduced prevalence of Plasmodium falciparum infection and of concomitant anaemia in pregnant women with heterozygous G6PD deficiency. Trop Med Int Health 2003; 8:118-24.
  3. Beutler E. G6PD deficiency. Blood. 1994; 84:3613–36.
  4. Reclos GJ, Hatzidakis CJ, Schulpis KH. Glucose-6-phos-phate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonates are missed during routine screening. J Med Screen 2000; 7:46-51.
  5. Carlo Corchia, Antonio Balata, Gian  Franco Meloni and Tullio MeloniFavism in a female newborn infant whose mother ingested fava beans before delivery, The Journal of Pediatrics, 127 (5)1995, : 807-808.
  6. Mason PJ. New insights into G6PD deficiency. Br J Hae-matol 1996; 94:585-91.
  7. CBBS e-Network Forums. Eligibility of prospective blood donors known to have G6PD deficiency. Accessed online July 20, 2005, at: http://www.cbbsweb.org/enf/donor_g6pd.html
  8. Sharma SC, Sharma S, Gulati OP. Pycnogenol prevents haemolytic injury in G6PD deficient human erythro-cytes. Phytother Res 2003; 17:671-4.
  9. Kornberg A, Horecker BL. Glucose-6-phosphate dehydrogenase. In: Colowick SP, Kaplan NO, editors. Methods in Enzymology. New York, NY: Academic Press; 1959.
  10. Chatterji SC, Das PK Chloramphenicol induced haemolyticanaemia due to enzymatic deficiency of erythrocytes. J Indian MedAssoc 40: 172, 1963.
  11. Chatterjee JB (1966) Hemoglobinopathies, G6PD deficiency and allied problems in the Indian Sub-continent. Bull WHO 35(6): 837-856.
  12. TP Sharma, Rajkumari (2010) Glucose-6-phosphate dehydrogenase deficiency in Danguria Tharu settled in Baharaich district of Uttar Pradesh. The Anthropologist 12(1): 59-61.
  13. Sharma SC, Sharma S, Gulati OP. Pycnogenol prevents haemolytic injury in G6PD deficient human erythro-cytes. Phytother Res 2003; 17:671-4.