This study uses annual time series data on under five mortality rate (U5MR) for Uruguay from 1960 to 2020 to predict future trends of U5MR over the period 2021 to 2030. Residuals and forecast evaluation criteria indicate that the applied ANN (12, 12, 1) model is stable in forecasting under five mortality rate. The ANN model projections revealed that annual U5MR will hover around 6 deaths per 1000 live births throughout the out of sample period. Therefore, authorities in Uruguay must continue providing financial support to the maternal and child health program in order to end all preventable under five deaths in the country.