This study uses annual time series data on under five mortality rate (U5MR) for Mozambique from 1963 to 2020 to predict future trends of U5MR over the period 2021 to 2030. Residuals and forecast evaluation criteria indicate that the applied ANN (12, 12, 1) model is stable in forecasting under five mortality rate. The ANN model projections revealed that U5MR will remain very high throughout the out of sample period. Therefore, we encourage the Mozambican government to address all the major challenges that hinder the success of the maternal and child health (MNCH) program and ensure availability of medical supplies and staff at all levels of healthcare.