This study uses annual time series data on under five mortality rate for Bangladesh from 1960 to 2020 to predict future trends of U5MR over the period 2021 to 2030. Residuals and model evaluation statistics indicate that the applied model is stable in forecasting under five mortality rate in Bangladesh. The ANN (12, 12, 1) projections revealed that U5MR will continue to decline over the out of sample period. Therefore, authorities in Bangladesh are encouraged to address various challenges encountered by under five children especially in the rural areas and marginalized communities where there are challenges in accessing quality healthcare services as a result of shortages of medical staff, inadequate medical supplies and poor health infrastructure.