This study uses annual time series data on under five mortality rate (U5MR) for Mexico from 1960 to 2020 to predict future trends of U5MR over the period 2021 to 2030. Residuals and forecast evaluation criteria indicate that the applied ANN (12, 12, 1) model is stable in forecasting under five mortality rate. ANN model projections revealed that U5MR will continue to decline throughout the out of sample period. Therefore, we implore the Mexican government to design local strategies that will keep under five mortality under control.