This study uses annual time series data on under five mortality rate (U5MR) for Niger from 1967 to 2020 to predict future trends of U5MR over the period 2021 to 2030. Residuals and forecast evaluation criteria indicate that the applied ANN (12, 12, 1) model is stable in forecasting under five mortality rate. ANN model projections revealed that U5MR will remain very high. Therefore, we encourage the government of Niger to address all the existing challenges in order to improve child survival and substantially reduce under five mortality to levels as low as 25 deaths per 1000 live births.