In this study, an overview of energy performance was obtained from the comparison of refrigerants (R32 to R1270 and R410a to R1270) in split inverter AC equipment. R32 testing was carried out with temperature settings of 16^oC and 27^oC while R410a was carried out with temperature settings of 18^oC and 27^oC. At each temperature setting, the cooling load is carried out under conditions using a heater and without loading. In this analysis, a comparison of energy performance and energy efficiency is carried out using the VDMA 24247-2 standard. The results of this study showed that the refrigeration effect value of R1270 was greater than R32 and R410a in all conditions. For compressor work, R1270 has a lower value than R32 and R410a because the value of ∆P (P₂-P₁) on R1270 is smaller so that the compressor work in the compression process is lower. In terms of system, the efficiency for R1270 in various conditions for replacing R32 is almost the same while for R1270 for replacing R410a, the highest efficiency is at a temperature setting of 16^oC, namely at 100% mass condition. Based on the VDMA 24247-2 standard, the highest total energy efficiency value in R32 is 17.17% while in R1270 with a mass of 90%, 100% and 110% is 18.15%, 21.09% and 21.86%. The highest total energy efficiency value in R410a is 5.44% while in R1270 with a mass of 90%, 100% and 110% is 6.25%, 6.22%, 7.42%.