Carbon Nanotubes for Neural Applications

Abstract

This research proposal investigates the feasibility of utilizing carbon nanotubes (CNTs) for neural applications. Due to their exceptional mechanical strength, electrical conductivity, and biocompatibility, CNTs present significant potential for biomedical uses. This study focuses on their role in peripheral nerve regeneration and as components of neural interfaces. We hypothesize that CNTs can promote nerve regeneration and serve as efficient neural electrodes due to their unique properties. The objectives include assessing biocompatibility, evaluating electrical properties, designing CNT-based scaffolds, and developing CNT-based microelectrodes. The expected outcomes will contribute to advancements in neural regeneration and neural interface technologies, with significant implications for prosthetics and neurological disorder treatments.

Country : India

1 Rithik Vinay P.S2 Shashank Sivakumar3 Prof. Dr. Saibol Ray

  1. Department of Student Research, SSVM World School, Coimbatore, Tamilnadu, India
  2. Department of Student Research, SSVM World School, Coimbatore, Tamilnadu, India
  3. Department of Student Research, SSVM World School, Coimbatore, Tamilnadu, India

IRJIET, Volume 8, Issue 4, April 2024 pp. 363-366

doi.org/10.47001/IRJIET/2024.804058

References

  1. Bekyarova, E., Ni, Y., Malarkey, E. B., Montana, V., McWilliams, J. L., Haddon, R. C., & Parpura, V. (2005). Applications of carbon nanotubes in biotechnology and biomedicine. *Journal of Biomedical Nanotechnology, 1*(1), 3-17.
  2. Kam, N. W. S., & Dai, H. (2006). Carbon nanotubes as intracellular protein transporters: Generality and biological functionality. *Journal of the American Chemical Society, 128*(3), 351-358.
  3. Mattson, M. P., Haddon, R. C., & Rao, A. M. (2000). Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth. *Journal of Molecular Neuroscience, 14*(3), 175-182.
  4. Pantarotto, D., Partidos, C. D., Graff, R., Hoebeke, J., Briand, J. P., Prato, M., & Bianco, A. (2003). Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides. *Journal of the American Chemical Society, 125*(20), 6160-6164.
  5. Rudge, S. R., Kurtz, T. L., Vesely, C. R., Catterall, L. G., & Williamson, D. L. (2000). Preparation, characterization, and performance of magnetic iron-carbon composite microparticles for biomedical applications. *Journal of Biomedical Materials Research, 50*(1), 70-80.
  6. Saito, N., Usui, Y., Aoki, K., Narita, N., Shimizu, M., Hara, K.,.. & Kato, H. (2009). Carbon nanotubes: Biomaterial applications. *Chemical Society Reviews, 38*(7), 1897-1903.
  7. Smart, S. K., Cassady, A. I., Lu, G. Q., & Martin, D. J. (2006). The biocompatibility of carbon nanotubes. *Carbon, 44*(6), 1034-1047.
  8. Wang, Y., Iqbal, Z., & Mitra, S. (2006). Rapidly functionalized, water-dispersed carbon nanotubes at high concentrations. *Journal of the American Chemical Society, 128*(1), 95-99.
  9. Yang, W., Thordarson, P., Gooding, J. J., Ringer, S. P., & Braet, F. (2007). Carbon nanotubes for biological and biomedical applications. *Nanotechnology, 18*(41), 412001.
  10. Zhang, Y., Ali, S. F., Dervishi, E., Xu, Y., Li, Z., Casciano, D., & Biris, A. S. (2010). Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. *ACS Nano, 4*(6), 3181-3186.