Faced with the growing importance of data security, this research aims to examine the Guinean legal and regulatory framework relating to the protection of scientific data. Through a systematic analysis of legal and regulatory provisions, enriched by interviews with key players in the academic and scientific community, the study evaluates the coherence and efficiency of legislation in Guinea with regard to international standards. Preliminary findings reveal the existence of notable progress but also significant deficits, particularly with regard to alignment with international data protection standards. On this basis, recommendations are put forward with the aim of improving the current legal and regulatory structure for optimal safeguarding of scientific data in the Republic of Guinea.