International Research Journal of Innovations in Engineering and Technology - IRJIET International Open Access, Monthly, Peer Reviewed, Reputed Journal ISSN (online): 2581-3048

Impact Factor (2025): 6.9

DOI Prefix: 10.47001/IRJIET

Insilico Approach to Find Bioactive Compound against Fruit Rot Disease (FRD) in Areca Catechu

Sharada S BAssociate Professor, Department of Biotechnology, Basaveshwar Engineering College, Bagalkote, Karnataka, IndiaAjay A ShettigarStudent of Biotechnology Engineering, Basaveshwar Engineering College, Bagalkote, Karnataka, IndiaBhuvaneshwariStudent of Biotechnology Engineering, Basaveshwar Engineering College, Bagalkote, Karnataka, IndiaShailashree C GanigerStudent of Biotechnology Engineering, Basaveshwar Engineering College, Bagalkote, Karnataka, India

Vol 8 No 7 (2024): Volume 8, Issue 7, July 2024 | Pages: 43-52

International Research Journal of Innovations in Engineering and Technology

OPEN ACCESS | Research Article | Published Date: 13-07-2024

doi Logo doi.org/10.47001/IRJIET/2024.807004

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Abstract

Phytophthora meadii is a fungal species which causes Fruit Rot Disease (FRD) in Areca catechu affects the quality and yield which is main threat for agricultural economy. Traditional methods include chemical fungicides like bordeaux mixture, Fosetyl-al, metalaxyl, mancozeb, copper oxychloride, cymoxalin, copper sulfate, etc in treatment of FRD, which can lead to environmental and health issues. In this study, an in silico approach was employed to identify potential bioactive compounds that could serve as effective agents against the pathogens responsible for FRD in Areca catechu. Utilizing a combination of molecular docking and virtual screening, we screened a comprehensive library of natural compounds for their ability to inhibit key enzymes and proteins associated with FRD pathogens. The molecular docking analysis focused on identifying compounds with high binding affinities to target proteins, suggesting their potential efficacy in disrupting pathogen activity. Among the screened compounds, several compounds have shown strong binding affinities indicating their potential as bioactive agents against FRD pathogens. These findings provide a promising foundation for the development of natural, environmentally-friendly treatments for FRD in Areca catechu.

Keywords

Areca catechu, Fruit Rot Disease, FRD, Molecular docking, bioactive compounds


Citation of this Article

Sharada S B, Ajay A Shettigar, Bhuvaneshwari, & Shailashree C Ganiger. (2024). Insilico Approach to Find Bioactive Compound against Fruit Rot Disease (FRD) in Areca Catechu. International Research Journal of Innovations in Engineering and Technology - IRJIET, 8(7), 43-52, Article DOI https://doi.org/10.47001/IRJIET/2024.807004

Licence Copyright (c) 2026 International Research Journal of Innovations in Engineering and Technology creative common licence This work is licensed under Creative common Attribution Non Commercial 4.0 Internation Licence
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