Muscular dystrophy, also known as Duchenne muscular dystrophy (DMD), is a fatal muscle disorder, changes to the DMD gene be the cause of this disease, DMD primarily impacts boys during childhood. For DMD there was no treatment available up until, in recent years, a range of curative approaches to Muscular Dystrophy have been under research; a few among them are development of corticosteroids, viral vector mediated gene therapy, exon skipping, etc. exon-skipping is the one of the optimistic approaches for correcting DMD, this therapy’s main aim is to transform an out-of-frame mutation to convert an out-of-frame mutation into an in-frame mutation, to change of a severe DMD phenotype into a mild phenotype by restoration of reduced dystrophin aspect.