International Research Journal of Innovations in Engineering and Technology - IRJIET International Open Access, Monthly, Peer Reviewed, Reputed Journal ISSN (online): 2581-3048

Impact Factor (2025): 6.9

DOI Prefix: 10.47001/IRJIET

Synthesis and Characterization of Porphyrin Carbohydrate Conjugate via “Click Chemistry”

Abstract

Recently, development of new photosensitizing agents for the potential application in photodynamic therapy has gain considerable attention. Porphyrin a highly conjugated macrocyclic organic system with high molar absorption coefficient is considered suitable candidate for development of new photosensitizing agent. Therefore, a novel Azido-β-D-lactosylated zinc (II) tetraphenyl porphyrin was synthesized by four reactions steps. The molecular structures of the synthesized compounds were characterized by IR, 1H-NMR and UV–Vis spectroscopy. The water solubility properties of target compound were studied by UV–Vis spectroscopy in mixed water/DMSO mixed solvent system with different range of water contents. The water content in DMSO ranges from 10% to 100% (v/v). When the water contents increase to 20% intensity of the Soret band gradually decreases with an increasing water-content up to 100% attributed to the solubility of the compound in water. The water solubiliy properties of the porphyrin carbohydrate conjugate enhances its potential application in photodynamic therapy.

Country : Nigeria

1 Abdulhamid Umar2 Hassan Wafi Garba

  1. Department of Chemistry, Adamawa State University, Mubi PMB 25 Mubi, Adamawa State, Nigeria
  2. Department of Chemistry, Adamawa State University, Mubi PMB 25 Mubi, Adamawa State, Nigeria

IRJIET, Volume 8, Issue 9, September 2024 pp. 1-7

doi.org/10.47001/IRJIET/2024.809001

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