ESTD Year: 2017 | Impact Factor: 6.9
DOI Prefix: 10.47001/IRJIET
Vol 10 No 9 (2026): Volume 10, Issue 9, September 2026 | Pages: 38-56
International Research Journal of Innovations in Engineering and Technology
OPEN ACCESS | Research Article | Published Date: 13-09-2026
Retinal diseases are becoming more frequent, leading to increased demand for large and diverse datasets in applying deep learning techniques in automated diagnoses. The problem with data from different health centers is that, due to various privacy laws, ethical concerns, and limitations on institutional data sharing, it is usually difficult to combine retina images into one centralized system. Federated learning offers a solution by allowing various institutions to train a model in collaboration without merging their patients' data into a single center. The objective of this paper is to review methods for federated learning in the context of classification of retinal diseases based on the analyses of patterns of retina images. A systematic literary search and selection process has been undertaken in order to get the relevant researches published between 2018 and 2025 from the major scientific databases. The selected works are analyzed and classified in accordance with federated learning strategies, distribution of data used, disease coverage, models used, and data protection methods. In addition, a comparative analysis was also conducted in order to figure out major trends, advantages of the discussed approaches, and weaknesses of the existing studies. The current study exposes the weakness of federated retinal learning frameworks, which mostly work towards single-disease classification and base their analyses on the overly simplified claims about data. The issues of communication efficiency, privacy-utility trade-offs, and lack of large-scale clinical validation seriously challenge the application of the existing frameworks. After discussing the results of the review, the authors identify the most important gaps in the available research and develop an approach for deal with the existing issues effectively.
Federated learning, retinal imaging, multi-disease classification, fundus photography, optical coherence tomography, privacy-preserving machine learning.
Divya Chunduri, & K. Suresh Babu. (2026). Federated Learning for Multi-Disease Retinal Image Classification: A Systematic Review, Taxonomy, and Future Directions. International Research Journal of Innovations in Engineering and Technology - IRJIET, 10(9), 38-56. Article DOI https://doi.org/10.47001/IRJIET/2026.109005
This work is licensed under Creative common Attribution Non Commercial 4.0 Internation Licence
J. De Fauw et al., “Clinically Applicable Deep Learning for Diagnosis and Referral in Retinal Disease,” Nature Medicine, vol. 24, pp. 1342–1350, 2018.
D. S. W. Ting et al., “Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes,” JAMA, vol. 318, no. 22, pp. 2211–2223, 2017.
M. J. Sheller et al., “Federated Learning in Medicine: Facilitating Multi-Institutional Collaborations Without Sharing Patient Data,” Scientific Reports, vol. 10, Article 12598, 2020.
B. McMahan, E. Moore, D. Ramage, S. Hampson, and B. A. y Arcas, “Communication-Efficient Learning of Deep Networks from Decentralized Data,” Proceedings of the 20th International Conference on Artificial Intelligence and Statistics, vol. 54, pp. 1273–1282, 2017.
J. Lo et al., “Federated Learning for Diabetic Retinopathy Classification and Microvasculature Segmentation Using Optical Coherence Tomography Angiography,” Ophthalmology Science, 2021, Art. no. 100069. DOI: 10.1016/j.xops.2021.100069.
H. Ran et al., “Federated Learning for Glaucoma Detection With 3D Optical Coherence Tomography,” British Journal of Ophthalmology, vol. 108, no. 8, 2024. DOI: 10.1136/bjo-2023-324188.
T. Baptista, C. Soares, T. Oliveira, and F. Soares, “Federated Learning for Computer-Aided Diagnosis of Glaucoma Using Retinal Fundus Images,” Applied Sciences, vol. 13, no. 21, Art. no. 11620, 2023. DOI: 10.3390/app132111620.
A.Nabil et al., “Federated Learning for Multi-Disease Ophthalmic Diagnostics using OCTA,” medRxiv, 2025. DOI: 10.1101/2025.04.25.25326431.
S. Pachade et al., “Retinal Fundus Multi-Disease Image Dataset (RFMiD): A Dataset for Multi-Disease Detection Research,” Data, vol. 6, no. 2, p. 14, 2021.
T. Li, B. Wang, C. Hu, H. Kang, H. Liu, K. Wang, and H. Fu, “Applications of deep learning in fundus images: A review,” Medical Image Analysis, vol. 69, Art. no. 101971, 2021.
T. Li, A. K. Sahu, M. Zaheer, M. Sanjabi, A. Talwalkar, and V. Smith, “Federated Optimization in Heterogeneous Networks,” Proceedings of Machine Learning and Systems, vol. 2, 2020.
J. Konečný, H. B. McMahan, F. X. Yu, P. Richtárik, A. T. Suresh, and D. Bacon, “Federated Learning: Strategies for Improving Communication Efficiency,” NIPS Workshop on Private Multi-Party Machine Learning, 2016.
K. Bonawitz et al., “Practical Secure Aggregation for Privacy-Preserving Machine Learning,” Proceedings of the 2017 ACM SIGSAC Conference on Computer and Communications Security, pp. 1175–1191, 2017.
C. Dwork and A. Roth, “The Algorithmic Foundations of Differential Privacy,” Foundations and Trends in Theoretical Computer Science, vol. 9, nos. 3–4, pp. 211–407, 2014.
Y. Zhao, M. Li, L. Lai, N. Suda, D. Civin, and V. Chandra, “Federated Learning with Non-IID Data,” arXiv preprint arXiv:1806.00582, 2018.
Z. Tang, H.-S. Wong, and Z. Yu, “Privacy-Preserving Federated Learning With Domain Adaptation for Multi-Disease Ocular Disease Recognition,” IEEE Journal of Biomedical and Health Informatics, vol. 28, no. 6, pp. 3219–3227, 2024. DOI: 10.1109/JBHI.2023.3305685.
A.Hanif et al., “Federated Learning for Multicenter Collaboration in Ophthalmology: Implications for Clinical Diagnosis and Disease Epidemiology,” Ophthalmology Retina, Vol. 6, no. 8, pp.650-656,2022.:10.1016/j.oret.2022.03.005.